AG Rieger

Head: Prof. Dr. Michael Rieger

Stem cells raise enormous hope and expectations for regenerative medicine. Since decades hematopoietic stem cell transplantation has become routine treatment for many blood disorders and cancer and is a prime example for successfully applied regenerative medicine. However, many fundamental questions must be addressed for improved therapeutic options in the future.

We focus our research on basic mechanisms that control stem cell fate decisions (self-renewal vs. differentiation, lineage choice, quiescence vs. proliferation). These fate decisions need to be strictly balanced for normal tissue regeneration and for emergency situations, and are dysregulated in diseases (e.g. cancer). We utilize various organ stem cell systems (hematopoietic cells, mammary gland, colon) from mice and humans to unravel molecular and functional clues how these decisions are integrated in normal stem cell biology and how malignant stem cells can be targeted for innovative disease treatment.

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Selected publications:

Bhayadia R. et al. The endogenous tumor suppressor microRNA-193b: therapeutic and prognostic value in acute myeloid leukemia. J Clin Oncol [Epub ahead of print] (2018)

Lang F. et al. Plastic CD34 and CD38 expression in adult B-cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations. Leukemia 31:731–734. (2017)

Malkomes P. et al. Selective AKT inhibition by MK-2206 represses colorectal cancer-initiating stem cells. Ann Surg Oncol 23:2849-57. (2016)

Haetscher N. et al. STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nature Commun. 6:8928. (2015)

Rabenhorst U. et al. Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal. Cell Reports 11(12):1847-55. (2015)

Thalheimer F.B. et al. Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells Stem Cell Reports 3(1):34-43. (2014)

Rengstl B. et al. Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells. PNAS 110:20729-34. (2013)

Rieger M.A. and Schroeder T. Hematopoiesis. Cold Spring Harb Perspect Biol 4:a008250. (2012)

Rieger M.A. et al. Hematopoietic cytokines can instruct lineage choice. Science, 325: 217-218. (2009)