Members

Khalil Abou Elardat

Post-Doctoral Fellow

+49 69 6301 7297

k.abouelaradat(at)dkfz-heidelberg.de

Biosketch

Khalil Abou Elardat – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Hs25A, Rm111
60590 Frankfurt am Main
E-Mail: k.abouelaradat(at)dkfz-heidelberg.de

Degrees
PhD (2011) Universiteit Gent (Ghent, Belgium)

Expertise and interests

My training is as a biologist with a focus on cancer biology. I have experience working on various types of solid and non-solid cancers from my lab work during my master’s thesis and beyond. My work has focused on the synthesis of high-throughput data to gain an understanding of the heterogeneity and progression of papillary thyroid carcinomas, low grade gliomas and glioblastomas, and currently myeloid neoplasms. Currently, I am responsible for the development and deployment of workflows for the analysis of next generation sequencing (NGS) data in the context of basic and clinical research in addition to diagnostics. My focus is on the translation of NGS results to meaningful actionable reports and the study of clonal evolution and heterogeneity of myeloid neoplasms.

Positions held

Since 2015Post-doctoral fellow at the University Hospital Frankfurt and the Core Genomics Facility at the DKTK Frankfurt/Mainz partner site
2012-2014Post-doctoral fellow at the Carl Gustav Carus Faculty of Medicine of the TU-Dresden
2004-2007PhD student at the Belgian Nuclear Research Center (SCK-CEN) in Mol, Belgium and in the department of bioscience engineering of the Universiteit Gent
2004MS student in the biology department of the American University of Beirut

My most important publications

For a full publication list, see here

Abou-El-Ardat K, Seifert M, Becker K, Eisenreich S, Lehmann M, Hackmann K, Rump A, Meijer G, Carvalho B, Temme A, Schackert G, Schröck E, Krex D, Klink B. (2017) Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. Neuro Oncol. 19, 546-557 [Pubmed][Journal]

Seifert M, Abou-El-Ardat K, Friedrich B, Klink B, Deutsch A. (2014) Autoregressive higher-order hidden Markov models: exploiting local chromosomal dependencies in the analysis of tumor expression profiles. PLoS One 9, e100295 [Pubmed][Journal]

Eisenreich S, Abou-El-Ardat K, Szafranski K, Campos Valenzuela JA, Rump A, Nigro JM, Bjerkvig R, Gerlach EM, Hackmann K, Schröck E, Krex D, Kaderali L, Schackert G, Platzer M, Klink B. (2013) Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing. PLoS One 8, e76623 [Pubmed][Journal]

 Grosse J, Wehland M, Pietsch J, Schulz H, Saar K, Hübner N, Eilles C, Bauer J, Abou-El-Ardat K, Baatout S, Ma X, Infanger M, Hemmersback R, Grimm D. (2012) Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids. FASEB J 26, 5124-5140 [Pubmed][Journal]

Abou-El-Ardat K, Monsieurs P, Anastasov N, Atkinson M, Derradji H, De Meyer T, Bekaert S, Van Criekinge W, Baatout S. (2012) Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells. Mutat Res 731, 27-40 [Pubmed][Journal]

Islam Alshamleh

PhD student

Madita Broj

MD Student

+49 69 6301 83958

madita.broj(at)me.com

Ada-Sophia Clees

MD Student

+49 69 6301 6130

Ada-Sophia(at)hotmail.de

Miriam Guadalupe Contreras Mostazo

PhD Student

+49 69 6301 83975

contrerasmostazo(at)ub.edu

Florian Gatzke

Medical Fellow

+49 69 6301 5556

florian.gatzke(at)kgu.de

Johanna Kreitz

PhD Student

+49 69 6301 84287

kreitz(at)med.uni-frankfurt.de

Biosketch

Johanna Kreitz – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Haus 25A, Rm 314
60590 Frankfurt am Main
E-Mail: kreitz(at)med.uni-frankfurt.de

Degrees

  • MPhil (2016), Robert Gordon University, Aberdeen, Scotland
  • BSc (2013), Robert Gordon University, Aberdeen, Scotland
  • BSc (2013), Hochschule Bonn-Rhein-Sieg, Rheinbach, Deutschland

Expertise and interests

Since September 2016 I am working as a PhD student in the lab of Prof Hubert Serve (Hematology/Oncology, University Hospital Frankfurt) with the aim to identify hypoxia induced metabolic shifts in acute myeloid leukemia (AML). As part of the Horizon 2020 HaemMetabolome project, I am gaining a great understanding of the complexities involved in leukemia development and treatment on genetic and molecular level. Preceding my PhD, I was a member of the research team CyanoSol at the Robert Gordon University in Aberdeen, Scotland where I completed my BSc and MPhil. The key focus of my studies was the bioremediation of cyanobacterial toxins from drinking water by exploiting bacterial isolates with cyanotoxin degrading activity. Here, I gained expertise in phylogenetic and functional characterization of bacteria, industrial cultivation of cyanobacteria and purification of cyanotoxins using high performance liquid chromatography.

Positions held 

since 2016    PhD student, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt   
2014- 2016Research Master Student, CyanoSol group, Robert Gordon University   
2013-2014Bachelor Student, CyanoSol group, Robert Gordon University   

My most important publications

For a full publication list, see here

 

 

 

Sofia Krujatz

MD Student

+49 69 6301 6130

Sina Kupke

Master Student

+49 69 6301 6130

Nina Kurrle

Principal Investigator

+49 69 6301 4941

kurrle(at)med.uni-frankfurt.de

Biosketch

Nina Kurrle – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Hs 25A, Rm 313
60590 Frankfurt am Main
E-Mail: kurrle@med.uni-frankfurt.de

Degrees

  • PhD (2014), Goethe University Frankfurt, Germany
  • Diploma degree biology (2008), Goethe University Frankfurt, Germany
  • Postgraduate diploma (2005), University of Otago, New Zealand

Expertise and interests

I was trained as a biochemist and cellular biologist. During my PhD, my research focused on molecular mechanisms involved in cell signaling, cell-cell and cell-matrix adhesion. In September 2013, I joined the department of Hematology/Oncology as a Post-Doc in a research project within the SFB815 (redox regulation) under supervision of Prof. Harald von Melchner and Prof. Hubert Serve focusing on the redox-sensitive regulation of mTORC1- and receptor tyrosine kinase-signaling by sestrin proteins. During this time, I gained extensive experience in the analysis of redox-dependent processes and genome-editing techniques in various cellular systems. In my current research, I focus on redox-dependent signal transduction pathways in acute myeloid leukemia (AML) and multiple myeloma (MM) with emphasis on bone-marrow microenvironmental cues to unravel molecular mechanisms involved in disease progression and to identify novel vulnerabilities for AML and MM treatment.

Positions held

since 2016    Postdoctoral Fellow, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt   
2013-2016 Postdoctoral Fellow, Molecular Hematology, University Hospital Frankfurt   
2009-2013PhD student, Institute of Biochemistry, JLU Giessen   

 

My most important publications

For a full publication list, see here

 

Tomasovic A*, Kurrle N*, Wempe F, De-Zolt S, Scheibe S, Koli K, Serchinger M, Schnütgen F, Sürün D, Sterner-Kock A, Weissmann N, von Melchner H. (2017) Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function. Matrix Biol 59, 109-120  *equally contributed [Pubmed][Journal]

 

Völlner F, Ali J, Kurrle N, Exner Y, Eming R, Hertl M, Banning A, Tikkanen R. (2016) Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes. Sci Rep 6, 28820 [Pubmed][Journal]

 

Tomasovic A*, Kurrle N*, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H. (2015) Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. 290, 9735-9752 [Pubmed][Journal]

 

Kurrle N, Völlner F, Eming R, Hertl M, Banning A, Tikkanen R. (2013) Flotillins directly interact with γ-catenin and regulate epithelial cell-cell adhesion. Plos One 8(12): e84393 [Pubmed][Journal]

  

Kurrle N, Ockenga W, Meister M, Völlner F, Kühne S, John BA, Banning A, Tikkanen R. (2013) Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells. BMC Cancer 1, 575 [Pubmed][Journal]

 

 

Miriam Kress

MD student

+49 69 6301 83958

kressmiriam(at)gmail.com

Philipp Makowka

Medical Fellow

+49 69 6301 6130

philipp.makowka(at)kgu.de

Ivana von Metzler

Principal Investigator

Heike Nuernberger

Technician

+49 69 6301 84287

nuernberger(at)em.uni-frankfurt.de

Biosketch

Heike Nuernberger – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Haus 25A, Rm 314
60590 Frankfurt am Main
E-Mail: nuernberger(at)em.uni-frankfurt.de

Expertise and interests

After completing my apprenticeship as a technical assistant (medicine), I joined the Central Institute for Microbiology and Experimental Medicine, which is now known as the HKI Leibnitz Institute for Natural Product Research, involved in projects including the isolation and characterization of antibiotics-producing bacteria. Gradually, I expanded my area of activity to molecular biology, establishing methods like gene cloning, PCR, sequencing, and heterologous gene expression. At that time, I contributed to unravel the biosynthesis pathway of Daunorubicine. In 1996, I joined the department of hematology/oncology as a technical assistant and further expanded my methodological repertoire to microarray-, protein- and RNA technologies. Today, I run a DNA manipulation core facility as a principal technical assistant. I am involved in the daily lab coordination and I am planning and conducting experiments e.g. using various gene editing methodologies like CRISPR/Cas9.

Positions held 

since 1996    Technician, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt   
1984-1995Technician, Dept. Antibiotics/Microbiology, HKI Jena   
1980-1983Apprenticeship Technical Assistant (Medicine), MeFa Jena  

My most important publications

Kalina U, Kauschat D, Koyama N, Nürnberger H, Ballas K, Koschmieder S, Bug G, Hofmann WK, Hoelzer D, Ottmann OG (2000) L-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J. Immunol 165,1307-1313 [Pubmed][Journal]

Krügel H, Schumann G, Hänel F, Fiedler G. (1993) Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation. (Acknowledgement) Mol Gen Genet 241, 193-202 [Pubmed][Journal]

Schumann G, Nürnberger H, Sandmann G, Krügel H. (1996) Activation and analysis of cryptic crt genes for carotenoid biosynthesis from Streptomyces griseus. Mol Gen Genet 252, 658-666 [Pubmed][Journal]

 

 

 

 

 

Anastasia Parmon

MD student

+49 69 6301 5556

aparmon95(at)gmail.com

Miriam Rehor

MD student

Birgit Rosiejak

Financial and Scientific Coordinator

Frank Schnütgen

Principal Investigator – Lab Coordinator

+49 69 6301 4941/5556

schnuetgen(at)em.uni-frankfurt.de

Biosketch

Frank Schnütgen – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Haus 25A, Rm 302
60590 Frankfurt am Main
E-Mail: schnuetgen(at)em.uni-frankfurt.de

Degrees

  • PhD (1997), Westfälische-Wilhelms-Universität Münster
  • Diploma in Chemistry (1993), Westfälische-Wilhelms-Universität Münster

Expertise and interests

I gained extensive experience in precise genome editing in eukaryotic cellular systems. At my start in Frankfurt, I developed a novel conditional gene trapping approach based on site specific recombinases that paved the way towards national and international large scale conditional mouse mutagenesis programs. At that time, I was responsible for vector development within the German Gene Trap Consortium (GGTC) and the European Conditional Mouse Mutagenesis (EUCOMM) program to which I contributed a large variety of different gene driven mutagenesis strategies. I was trained as a Biochemist, Molecular and Cellular Biologist. My current research focus lies in the influence of the microenvironment on leukemic cell behavior, gene editing and genome-wide genetic screens as well as in the development of techniques for the gene therapy of monogenic diseases using the CRISPR/Cas9 technology.

Positions held 

since 2016     Lab Coordinator, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt   
Since 2008 Facility Manager of Genetic Engineering   
2001-2016 Postdoctoral Fellow, Molecular Hematology, University Hospital Frankfurt   
1998-2000 Postdoctoral Fellow, IGBMC, Illkirch, Strasbourg, France   
1993-1997 PhD student, Dept. of Biochemistry, WWU Münster   
1996 Visiting Scientist, Albert-Einstein-College of Medicine, New York, USA    
1993 Diploma degree chemistry, WWU Münster    

My most important publications

For a full publication list, see here

Sürün, D., Schwäble, J., Tomasovic, A., Eilig, R., Stein, S., Kurrle, N., von Melchner, H., and Schnütgen, F. (2018) High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing. Mol Ther Nucleic Acids. 10: 1–8. [Pubmed][Journal

Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schmauss G, Schramek D, Schnuetgen F, von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A, Penninger JM. (2011) Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell 9, 563-574 [Pubmed][Journal]


Schnütgen F, Ehrmann F, Poser I, Hubner NC, Hansen J, Floss T, deVries I, Wurst W, Hyman A, Mann M, von Melchner H. (2011) Resources for proteomics in mouse embryonic stem cells. Nat Methods 8, 103-104 [Pubmed][Journal]


Schnütgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H. (2008) Enhanced gene trapping in mouse embryonic stem cells. Nucleic Acids Res 36, e133 [Pubmed][Journal]


Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H. (2005) Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. Proc Natl Acad Sci USA 102, 7221-7226 [Pubmed][Journal]


Schnütgen F, Doerflinger N, Calléja C, Wendling O, Chambon P, Ghyselinck NB. (2003) A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol 21, 562-565 [Pubmed][Journal]

 

 

 

Christine Schönfeld

PhD Student

+49 69 6301 84287

schönfeld(at)med.uni-frankfurt.de

Biosketch

Christine Schönfeld – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Hs25A, Rm313/314
60590 Frankfurt am Main
E-Mail: c.schoenfeld(at)dkfz.uni-heidelberg.de

Expertise and interests

During my academic studies at the TU Dortmund, I obtained great insights into the field of chemistry and biochemistry. In order to obtain more expertise in cell biology, I performed my master project in systemic cell biology at the Max Planck Institute of Molecular Physiology in Dortmund, where I focused on the regulation of extracellular signal-regulated kinase (ERK) signaling by using dual specific phosphatases (DUSP). In this position, I gained excellent experiences in performing several different microscopy techniques. To detect the phosphorylation state of ERK in the presence of DUSP I used live cell imaging and fluorescence lifetime imaging microscopy. In 2016, I started my PhD studies in the department of hematology and oncology at the University Hospital Frankfurt where I aim to identify altered biomarkers which are responsible for drug resistance. In order to develop a forward genetic screen, I generate drug resistance phenotypes using several anti-leukemic drugs. Discovery of drug resistant genes and their interactors are of clinical relevance and their presence will also be analyzed in leukemic patient samples.

Positions held

Since 2016PhD student, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt
2013-2016Master of Science in Chemical Biology, TU Dortmund, Max Planck Institute of Molecular Physiology
2010-2013Bachelor of Science in Chemical Biology, TU Dortmund

My most important publications

For a full publication list, see here

Marcel Seibert

PhD Student

+49 69 6301 6130

seibert(at)med.uni-frankfurt.de

Biosketch

Marcel Seibert – Biosketch

 

Address

Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Hs25A, Rm311/312
60590 Frankfurt am Main
E-mail: seibert(at)med.uni-frankfurt.de

Degree

  • M.Sc. Biochemistry (2017), Goethe-University Frankfurt, Deutschland
  • B.Sc. Biology (2014), TU Darmstadt, Deutschland

Expertise and interests

Since September 2017 I am working as a PhD student in the lab of Prof Hubert Serve (Hematology/ Oncology, University Hospital Frankfurt) focusing on the molecular mechanism of Multiple Myeloma - a cancer of plasma cells.

During my master studies, I was trained as a biochemist and cellular biologist with great interests in immunology gaining methodological experience to understand diseases affecting immune cells. Due to my interest in cancer biology, I will now proceed my scientific education combining immunological and oncological approaches thereby understanding cancer driving mechanisms to identify novel therapeutic targets in Multiple Myeloma.

Positions held

since 2017 PhD student, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt
2014- 2017Master of Science in Biochemistry, Master Student in the Paul-Ehrlich-Institute, Division of Immunology
2011-2014Bachelor Student in Biology, Bachelor Student in the GSI Helmholtz Centre for Heavy Ion Research

My most important publications

For a full publication list, see here

 

 

 

 

Hubert Serve

Lab head

+49 69 6301 5194

Biosketch

Hubert Serve – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Haus 23A
60590 Frankfurt am Main
E-Mail: serve(at)em.uni-frankfurt.de

Degrees
MD (1988), Ruprecht-Karls-Universität Heidelberg,

Expertise and interests

Since 2007, I am Full Professor and Department Director in Frankfurt. This includes the coordination of the Scientific programs of the cancer center (UCT), of the Frankfurt/Mainz site of the German Cancer Consortium (DKTK) and of the LOEWE Center for Cell and Gene Therapy, all externally funded. Nationally, I coordinate the DKTK structure that is responsible to connect laboratory to clinical research (CCP). Additionally, I act as a reviewer and advisor to many national and international funding agencies and journals. I was trained as a Hematologist, a Medical Oncologist and as a Molecular Biologist. My research focus lies in leukemia research with an emphasis on its cellular and molecular pathogenesis. Currently, I work on the discovery of predictive markers and of treatment response mechanisms. Clinically, I am an expert for AML and I am a leading figure in trial groups on acute Leukemias.

Positions held

Since 2011Coordinator of the Frankfurt/Mainz site of the "German Cancer Consortium (DKTK)“
Since 2008Scientific Director of the University Cancer Center Frankfurt
since 2007Director of the Department of Medicine, Hem/Onc, Goethe University Frankfurt
2002-2007Associate Professor, Hematology/Oncology at the University of Münster
1997-2007Attending Physician (Hematology/Oncology) University of Münster
1994-1997Physician in Training, Freie Universität Berlin
1991-1994Postdoctoral Fellow, Memorial Sloan Kettering CC, New York
1990-1991Physician in Training, Ulm University
1988-1990Physician in Training, TU München

My most important publications

For a full publication list, see here

Verena Stolp

PhD Student

+49 69 6301 6130

verena.stolp(at)t-online.de

Biosketch

Verena Stolp – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Hs25A, Rm311
60590 Frankfurt am Main
E-Mail: verena.stolp(at)t-online.de

Expertise and interests

Recently, I completed my Master studies in Molecular Medicine at the Goethe University in Frankfurt. The main aspects of this program are cardiovascular, pharmaceutical and cancer research and most of my practical courses centered on cancer-related topics. Since I am especially interested in leukemia research and aimed to learn the CRISPR/Cas9 method, I joined the Serve group in February 2017 for my Master thesis. My master project focused on the leukemic microenvironment of acute myeloid leukemia cells. More precisely, I analyzed the influence of components of the bone marrow niche on the cancer cell's maintenance, while in a second part of the project, I tried to establish a genetic screening system to investigate critical aspects for the support of leukemia progression. I am now extending my stay at the Serve lab as a PhD student in the interdisciplinary research program DynaMem, "Membrane dynamics: Molecular basic principles and theoretical description". Within this project, my topic centers on membrane dynamics and its role in pathogenesis of Multiple Myeloma. My general aim is to identify molecular mechanisms triggering loss of osteoclast function in Multiple Myeloma patients.

Positions held

since 2018PhD student, Dept. of Medicine 2, Hematology/Oncology

2014-2017

Master Molecular Medicine, University Frankfurt
08/2016–01/2017Internship Merck, Oncology Cellular Pharmacology
04/2016–06/2016Internship Sanofi, Chronic Inflammatory Diseases
2011–2014Bachelor Biological Sciences, University Frankfurt

 

 

 

Pawel Piotr Szczesniak

Post-Doctoral Fellow

+49 69 6301 6358

szczesniak(at)med.uni-frankfurt.de

Biosketch

Pawel Piotr Szczesniak – Biosketch

Address
Department of Medicine 2, Hematology/Oncology
University Hospital Frankfurt
Goethe University
Theodor-Stern-Kai 7
Haus 25A, Rm 303
60590 Frankfurt am Main
E-Mail: szczesniak(at)med.uni-frankfurt.de

Degrees

  • PhD (2016), Justus Liebig University Giessen

Expertise and interests

A keen interest in life sciences has led me to my current projects on the pathophysiology of cancer and the development of putative therapy options. My background includes biophysics and molecular cell biology. Here at the University Hospital Frankfurt I have embarked on a project on acute myeloid leukemia (AML). I am focusing on developing and validating new strategies to target AML cells, in particular by interfering with the ubiquitin-proteasome system (UPS). The assessment of clinically actionable inhibitors will be performed with immortalized AML cells as well as primary AML blasts from patients. Protein turnover will be assessed with quantitative mass spectrometry-based proteomics whereas genetic vulnerabilities and susceptibility will be identified using clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-based genetic screens.

Positions held 

since 2016    Post-Doctoral Fellow, Dept. of Medicine 2, Hematology/Oncology, University Hospital Frankfurt   
2012-2016PhD student, Institute for Anatomy, Faculty of Medicine, Justus-Liebig University Giessen   
2010-2012Research Assistant, Max Planck Institute (MPI) for Heart and Lung Research, Department of Lung Development and Remodeling, Bad Nauheim    
2010Master of Science in Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland   
2009-2010Research Assistant, Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland   
2009Research Assistant, Center for Molecular Biophysics (CBM), French National Center for Scientific Research (CNRS), Orléans, France     

My most important publications

For a full publication list, see here

Szczęśniak P, Meinhardt A, Klug J. Macrophage migration inhibitory factor (MIF) but not its homologue D-dopachrome tautomerase (D-DT) promotes fibroblast motility in a CD44/CD74-independent manner. (manuscript under revision)

Li, J.H., Tang, Y., Tang, P., Lv, J., Huang, X.R., He, Z. J., Zhou, Z. J., Huang, Q. Y., Carlsson-Skwirut, C., Da Costa, L., Dianzani, I., Fröhlich, S., Szczęśniak, P., Klug, J., Meinhardt, A., Fingerle-Rowson, G., Bucala, R., Xu, A.P., Lan, H.Y. (2018) Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Mol Ther. Jul 17. pii: S1525-0016(18)30339-3. doi: 10.1016/j.ymthe.2018.07.014 [journal]

Knoepp F, Ashley Z, Barth D, Kazantseva M, Szczęśniak P, Clauss WG, Althaus M, Alvarez de la Rosa D, Fronius M. (2017) Mechanical activation of epithelial Na+ channel relies on an interdependent activity of the extracellular matrix and extracellular N-glycans of αENaC. bioRxiv 102756; doi: doi.org/10.1101/102756 [journal]

Conference abstracts

Szczęśniak P, Meinhardt A, Klug J. (2017) Macrophage migration inhibitory factor (MIF) but not its homologue D-dopachrome tautomerase (D-DT) promotes fibroblast motility in a CD44/CD74-independent manner. FASEB J April 2017 31:880.1. Experimental Biology conference abstract. [journal]

Knoepp F, Szczęśniak P, Althaus M, Fronius M. (2015) Glycosylated extracellular asparagines of the α-subunit provide a connection to the extracellular matrix and facilitate the shear force-dependent activation of the human epithelial Na+-channel (ENaC). FASEB J April 2015 29:845.1. Experimental Biology conference abstract. [journal]

 

 

 

Rosa Toenges

Medical Fellow

+49 69 6301 83975

rosa.toenges(at)kgu.de

Sandra Tzschentke

Technician

+49 69 6301 84287

Sebastian Wagner

Principal Investigator

+49 69 6301 84004/6358

Sebastian.Wagner(at)kgu.de

Sarah Weber

Medical Fellow

+49 69 6301 83958

sarah.weber(at)kgu.de

Frank Wempe

Post-Doctoral Fellow

+49 69 6301 4941/6130

wempe(at)em.uni-frankfurt.de